Cantharidic Acid

(HB0167)

Product overview

  • Name
    Cantharidic Acid
  • Short description
    Potent, selective PP2A inhibitor
  • Biological description
    Potent and selective protein phosphatase 2A (PP2A) inhibitor (IC50 = 53 nM). Selective for PP2A over PP1 (IC50 = 562 nM). Potentiates cyclic-AMP Response element binding (CREB) signalling (EC50 = 0.45 µM). Increases transduction of adenovirus vectors. Shows apoptotic actions.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    2,3-Dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
  • Molecular Weight
    214.21
  • Molecular Formula
    C10H14O5
  • CAS Number
    28874-45-5
  • PubChem identifier
    121475
  • SMILES
    C[C@]1([C@H]2CC[C@@H]([C@]1(C)C(=O)O)O2)C(=O)O
  • InChi
    InChI=1S/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9+,10-
  • InChiKey
    NMTNUQBORQILRK-XCVPVQRUSA-N

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100 mM) and in ethanol (25 mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Cantharidic Acid

  • Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory.

    Xia M et al (2009) Proc Natl Acad Sci U S A 106(7) : 2412-7.
    PubMedID: 19196967
  • Suppression of protein phosphatase 2A activity enhances Ad5/F35 adenovirus transduction efficiency in normal human B lymphocytes and in Raji cells.

    Cayer MP et al (2012) J Immunol Methods 376(1-2) : 113-24.
    PubMedID: 22210093
  • Structure activity analysis of the pro-apoptotic, antitumor effect of nitrostyrene adducts and related compounds.

    Kaap S et al (2003) Biochem Pharmacol 65(4) : 603-10.
    PubMedID: 12566088

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