Product overview

Name Cantharidic Acid
Purity >98%
Description Potent, selective PP2A inhibitor
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Biological Data

Biological description Potent and selective protein phosphatase 2A (PP2A) inhibitor (IC50 = 53 nM). Selective for PP2A over PP1 (IC50 = 562 nM). Potentiates cyclic-AMP Response element binding (CREB) signalling (EC50 = 0.45 µM). Increases transduction of adenovirus vectors. Shows apoptotic actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM) and in ethanol (25 mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 2,3-Dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
Molecular Weight 214.21
Molecular Formula C10H14O5
CAS Number 28874-45-5
PubChem identifier 121475
SMILES C[C@]1([C@H]2CC[C@@H]([C@]1(C)C(=O)O)O2)C(=O)O
InChi InChI=1S/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9+,10-
InChiKey NMTNUQBORQILRK-XCVPVQRUSA-N

References for Cantharidic Acid

References are publications that support the biological activity of the product
  • Suppression of protein phosphatase 2A activity enhances Ad5/F35 adenovirus transduction efficiency in normal human B lymphocytes and in Raji cells.

    Cayer MP et al (2012) J Immunol Methods 376(1-2) : 113-24.
  • Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory.

    Xia M et al (2009) Proc Natl Acad Sci U S A 106(7) : 2412-7.
  • Structure activity analysis of the pro-apoptotic, antitumor effect of nitrostyrene adducts and related compounds.

    Kaap S et al (2003) Biochem Pharmacol 65(4) : 603-10.

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