Capsazepine

(HB1040)

Product overview

  • Name
    Capsazepine
  • Short description
    TRPV1 channel antagonist
  • Biological description
    TRPV1 channel antagonist (IC50 = 562 nM). Converts N+, K+-ATPase into Na+-ATPase. Synthetic analog of capsaicin and competitive capsaicin antagonist. Displays analgesic and anticonvulsant properties.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
  • Molecular Weight
    376.9
  • Chemical structure
    Capsazepine  [138977-28-3]
  • Molecular Formula
    C19H21ClN2O2S
  • CAS Number
    138977-28-3
  • PubChem identifier
    2733484
  • SMILES
    C1CC2=CC(=C(C=C2CN(C1)C(=S)NCCC3=CC=C(C=C3)Cl)O)O
  • InChi
    InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
  • InChiKey
    DRCMAZOSEIMCHM-UHFFFAOYSA-N
  • MDL number
    MFCD00153778

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in ethanol (25mM) and in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Capsazepine

  • Capsazepine, a synthetic vanilloid that converts the Na,K-ATPase to Na-ATPase.

    Mahmmoud YA (2008) Proc Natl Acad Sci U S A 105(5) : 1757-61.
    PubMedID: 18230728
  • Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin.

    Seabrook GR et al (2002) J Pharmacol Exp Ther 303(3) : 1052-60.
    PubMedID: 12438527
  • The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin.

    Walpole CS et al (1994) J Med Chem 37(13) : 1942-54.
    PubMedID: 8027976
  • TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo.

    Gonzalez-Reyes LE et al (2013) Exp Neurol 250 : 321-32.
    PubMedID: 24145133

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