CCCP

CCCP is a protonophore which is a widely used uncoupler of mitochondrial oxidative phosphorylation.

CCCP disrupts ATP synthesis by transporting protons across the mitochondrial inner membrane, interfering with the proton gradient.

By depolarizing the plasma membrane and reducing ATP production, CCCP can indirectly affect proton pump activity and cellular metabolism to cause cell death.

The uncoupling agent FCCP is also available.