CDPPB

(HB0175)

Product overview

  • Name
    CDPPB
  • Short description
    Selective mGlu5 positive allosteric modulator
  • Biological description
    Selective mGlu5 receptor positive allosteric modulator (EC50 = 27 nM for human mGlu5 receptor). Shows anti-psychotic and cognitive enhancing actions. Blood-brain barrier permeable.
  • Biological action
    PAM
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
  • Molecular Weight
    364.4
  • Chemical structure
    CDPPB  [781652-57-1]
  • Molecular Formula
    C23H16N4O
  • CAS Number
    781652-57-1
  • PubChem identifier
    11245456
  • SMILES
    C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=CC(=C3)C#N)C4=CC=CC=C4
  • Source
    Synthetic
  • InChi
    InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)
  • InChiKey
    BKUIZWILNWHFHD-UHFFFAOYSA-N
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (75mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CDPPB

  • A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.

    Kinney GG et al (2005) J Pharmacol Exp Ther 313(1) : 199-206.
    PubMedID: 15608073
  • Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning task performance in rodents.

    Fowler SW et al (2013) Neurobiol Learn Mem 99 : 25-31.
    PubMedID: 23137441
  • Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration.

    Parmentier-Batteur S et al (2012) Neuropharmacology 62(3) : 1453-60.
    PubMedID: 21112344