Ceftriaxone disodium salt

(HB0176)

Product overview

  • Name
    Ceftriaxone disodium salt
  • Short description
    β-lactam antibiotic. Increases EAAT2 activity.
  • Biological description
    β-lactam antibiotic. Increases EAAT2 expression and EAAT2 biochemical and functional activity. Potentially reduces glutamergic toxicity. Shows neuroprotective actions in neurodegenerative disease models and antinociceptive effects in neuropathic pain.
  • Biological action
    Antibiotic
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt
  • Molecular Weight
    598.54
  • Molecular Formula
    C18H16N8Na2O7S3
  • CAS Number
    74578-69-1
  • PubChem identifier
    9570985
  • SMILES
    CN1C(=NC(=O)C(=N1)[O-])SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+].[Na+]
  • InChiKey
    YOBPSXOHCHDCMU-VKZZUTNHSA-L
  • MDL number
    MFCD01750405
  • Appearance
    White to off-white

Storing and Using Your Product

  • Storage instructions
    +4 °C;
  • Solubility overview
    Soluble in DMSO (50 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Ceftriaxone disodium salt

  • Ceftriaxone mediated rescue of nigral oxidative damage and motor deficits in MPTP model of Parkinson's disease in rats.

    Bisht R et al (2014) Neurotoxicology 44 : 71-9.
    PubMedID: 25053526
  • Ceftriaxone, a beta-lactam antibiotic, modulates apoptosis pathways and oxidative stress in a rat model of neuropathic pain.

    Amin B et al (2014) Biomed Res Int 2014 : 937568
    PubMedID: 25028668
  • Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes.

    Lee SG et al (2008) J Biol Chem 283(19) : 13116-23.
    PubMedID: 18326497

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