Product overview

Name Ceftriaxone disodium salt
Purity >98%
Description β-lactam antibiotic. Increases EAAT2 activity.
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Biological Data

Biological description β-lactam antibiotic. Increases EAAT2 expression and EAAT2 biochemical and functional activity. Potentially reduces glutamergic toxicity. Shows neuroprotective actions in neurodegenerative disease models and antinociceptive effects in neuropathic pain.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt
Molecular Weight 598.54
Molecular Formula C18H16N8Na2O7S3
CAS Number 74578-69-1
PubChem identifier 9570985
SMILES CN1C(=NC(=O)C(=N1)[O-])SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)[O-].[Na+].[Na+]
InChiKey YOBPSXOHCHDCMU-VKZZUTNHSA-L
MDL number MFCD01750405
Appearance White to off-white

References for Ceftriaxone disodium salt

References are publications that support the biological activity of the product
  • Ceftriaxone, a beta-lactam antibiotic, modulates apoptosis pathways and oxidative stress in a rat model of neuropathic pain.

    Amin B et al (2014) Biomed Res Int 2014 : 937568
  • Ceftriaxone mediated rescue of nigral oxidative damage and motor deficits in MPTP model of Parkinson's disease in rats.

    Bisht R et al (2014) Neurotoxicology 44 : 71-9.
  • Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes.

    Lee SG et al (2008) J Biol Chem 283(19) : 13116-23.

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