CA200931 CellAura fluorescent GABAB antagonist [CGP-54626A]

(HB7830)

Product overview

  • Name
    CA200931 CellAura fluorescent GABAB antagonist [CGP-54626A]
  • Short description
    Fluorescent GABAB receptor antagonist
  • Biological description

    Fluorescent GABAB antagonist (pKD = 7.97). A fluorescent GABAB receptor ligand derived from CGP-54626A GABAB antagonist. Shown to antagonize the activity of the GABA.

  • Alternative names
    CA200931 | GB-633-AN | GABAB antagonist [CGP-54626A]
  • Biological action
    Antagonist
  • Purity
    >97%
  • Our products in action

Properties

  • Molecular Weight
    943
  • Source
    Synthetic
  • Formulation
    Lyophilized film
  • Excitation
    633 nm
  • Emission
    650 nm

Applications

  • Application notes
    For imaging at the GABAB1/B2 receptor use solutions up to 100 nM.
  • Pharmacological validation

    The CA200931 Fluorescent GABAB receptor antagonist was shown to antagonize the activity of the GABAB agonist, GABA, in a recombinant CHO cell line expressing the human GABAB1 and GABAB2 receptors and a serum-responsive secreted placental alkaline phosphatase (SPAP) reporter gene. The serum-induced expression of SPAP was measured under basal and serum-stimulated (maximal) conditions. Addition of CA200931 to the basal or serum-stimulated cells did not significantly alter basal and stimulated SPAP levels, demonstrating that the CA200931 fluorescent GABAB receptor antagonist has no intrinsic agonist activity.

Storing and Using Your Product

  • Storage instructions
    -20°C, protect from light
  • Solubility overview
    Soluble in DMSO
  • Handling
    After thawing individual aliquots for use, we recommend briefly sonicating the sample to ensure it is fully dissolved and the solution is homogeneous. We do not recommend using the product after subjecting it to repetitive freeze-thaw cycles.
  • Shipping conditions
    The product, supplied in a dry form, is stable at ambient temperature for periods of up to a few days and does not require shipping on ice/dry ice.
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

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