Product overview

  • Name
    CFM-2
  • Short description
    Selective, non-competitive AMPA receptor antagonist
  • Biological description
    Selective and non-competitive AMPA receptor antagonist. Inhibits ERK1/2 pathway and acts as an antiproliferative agent. Also shows anticonvulsant actions.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    1-(4'-Aminophenyl)-3,5-dihydro-7,8-dimethoxy-4H-2,3-benzodiazepin-4-one
  • Molecular Weight
    311.34
  • Chemical structure
    CFM-2  [178616-26-7]
  • Molecular Formula
    C17H17N3O3
  • CAS Number
    178616-26-7

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)

References for CFM-2

  • Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats.

    De Sarro G et al (1999) Eur J Pharmacol 368(2-3) : 149-59.
    PubMedID: 10193651
  • AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth.

    Stepulak A et al (2007) Cancer Biol Ther 6(12) : 1908-15.
    PubMedID: 18059166
  • 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.

    Chimirri A et al (1997) J Med Chem 40(8) : 1258-69.
    PubMedID: 9111300