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Product overview

  • Name
    CGP 35348
  • Short description
    Selective GABAB receptor antagonist
  • Biological description
    Selective GABAB receptor antagonist (IC50 = 34 µM). Improves learning and neuromuscular function in a model of ischemia. Shows pro-epileptic actions. Blood-brain barrier permeable.
  • Biological action
  • Citations


  • Chemical name
    (3-Aminopropyl)(diethoxymethyl)phosphinic acid
  • Molecular Weight
  • Chemical structure
    CGP 35348  [123690-79-9]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in water (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CGP 35348

  • CGP 35348: a centrally active blocker of GABAB receptors.

    Olpe HR et al (1990) Eur J Pharmacol 187(1) : 27-38.
    PubMedID: 2176979
  • CGP 35348, GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage.

    Gillani Q et al (2014) Biomed Res Int 2014 : 295215
    PubMedID: 24804211
  • Involvement of GABA(B) receptors in convulsant-induced epileptiform activity in rat neocortex in vitro.

    Sutor B et al (1998) Eur J Neurosci 10(11) : 3417-27.
    PubMedID: 9824455
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