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CGP55845 hydrochloride

(HB0960)
Data

Product overview

  • Name
    CGP55845 hydrochloride
  • Short description
    Potent, selective GABAB receptor antagonist
  • Biological description

    CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist (IC50 = 5 nM). It inhibits [3H]CGP 27492 binding (pKi = 8.35).


    CGP55845 hydrochloride inhibits GABA and glutamate release and inhibits GABAB receptor responses to baclofen (IC50 = 130 nM in an isoproterenol assay).


    It enhances responses to hypoglycaemia and shows convulsive actions at high doses.

  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride
  • Molecular Weight
    438.71
  • Chemical structure
    CGP 55845 hydrochloride  [149184-22-5]
  • Molecular Formula
    C18H22Cl2NO3P.HCl
  • CAS Number
    149184-22-5
  • PubChem identifier
    5311042
  • SMILES
    C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O
  • Source
    Synthetic
  • InChi
    InChI=1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1
  • InChiKey
    ZODSPDOOCZZEIM-BBRMVZONSA-N
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CGP55845 hydrochloride

  • GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors.

    Waldmeier PC et al (1994) Br J Pharmacol 113(4) : 1515-21.
    PubMedID: 7889310
  • Functional characterization and expression of thalamic GABA(B) receptors in a rodent model of Parkinson's disease.

    de Groote C et al (1999) Neuropharmacology 38(11) : 1683-9.
    PubMedID: 10587084
  • Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body.

    Zhang M et al (2007) J Physiol 578(Pt 3) : 735-50.
    PubMedID: 17124268
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