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CGP55845 hydrochloride

(HB0960)
Data

Product overview

  • Name
    CGP55845 hydrochloride
  • Short description
    Potent, selective GABAB receptor antagonist
  • Biological description

    CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist (IC50 = 5 nM). It inhibits [3H]CGP 27492 binding (pKi = 8.35).


    CGP55845 hydrochloride inhibits GABA and glutamate release and inhibits GABAB receptor responses to baclofen (IC50 = 130 nM in an isoproterenol assay).


    It enhances responses to hypoglycaemia and shows convulsive actions at high doses.

  • Biological action
    Antagonist
  • Purity
    >98%
  • Customer comments

    Works great! Switching to Hello Bio CGP 55845 from another supplier has saved us literally hundreds of dollars in the last year without sacrificing any quality at all! Indistinguishable in all regards except price. We love it! Verified customer, University of Toronto

  • Citations

Properties

  • Chemical name
    (2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride
  • Molecular Weight
    438.71
  • Chemical structure
    CGP 55845 hydrochloride  [149184-22-5]
  • Molecular Formula
    C18H22Cl2NO3P.HCl
  • CAS Number
    149184-22-5
  • PubChem identifier
    5311042
  • SMILES
    C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O
  • Source
    Synthetic
  • InChi
    InChI=1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1
  • InChiKey
    ZODSPDOOCZZEIM-BBRMVZONSA-N
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CGP55845 hydrochloride

  • GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors.

    Waldmeier PC et al (1994) Br J Pharmacol 113(4) : 1515-21.
    PubMedID: 7889310
  • Functional characterization and expression of thalamic GABA(B) receptors in a rodent model of Parkinson's disease.

    de Groote C et al (1999) Neuropharmacology 38(11) : 1683-9.
    PubMedID: 10587084
  • Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body.

    Zhang M et al (2007) J Physiol 578(Pt 3) : 735-50.
    PubMedID: 17124268
Support & Resources

Reviews & Product Guides

Reviews

  • Verified customer, University of Toronto

    Works great! Switching to Hello Bio CGP 55845 from another supplier has saved us literally hundreds of dollars in the last year without sacrificing any quality at all! Indistinguishable in all regards except price. We love it!