Chaetocin

(HB1415)

Product overview

  • Name
    Chaetocin
  • Short description
    Potent histone methyltransferase SUV39H1 inhibitor
  • Biological description
    Potent histone methyltransferase SUV39H1 inhibitor (IC50 = 0.8 µM). Induces reactive oxygen species. Shows apoptotic and anti-cancer actions.
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS) -2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl )-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio -11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4 ,4'-tetrone
  • Molecular Weight
    696.84
  • Chemical structure
    Chaetocin  [28097-03-2]
  • Molecular Formula
    C30H28N6O6S4
  • CAS Number
    28097-03-2

Storing and Using Your Product

  • Storage instructions
    -20°C
  • Solubility overview
    soluble in DMSO (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Chaetocin

  • Reply to 'Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases'.

    Greiner D et al (2013) Nat Chem Biol 9(3) : 137
    PubMedID: 23416388
  • Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism.

    Dixit D et al (2014) Cell Death Dis 5 : e1212.
    PubMedID: 24810048
  • The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation.

    Isham CR et al (2012) Br J Cancer 106(2) : 314-23.
    PubMedID: 22187030
  • Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

    Cherblanc FL et al (2013) Nat Chem Biol 9(3) : 136-7.
    PubMedID: 23416387

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