Product overview

Name Chaetocin
Purity >99%
Description Potent histone methyltransferase SUV39H1 inhibitor
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Biological Data

Biological description Potent histone methyltransferase SUV39H1 inhibitor (IC50 = 0.8 µM). Induces reactive oxygen species. Shows apoptotic and anti-cancer actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >99%
Chemical name (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS) -2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl )-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio -11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4 ,4'-tetrone
Molecular Weight 696.84
Chemical structure Chaetocin  [28097-03-2] Chemical Structure
Molecular Formula C30H28N6O6S4
CAS Number 28097-03-2
PubChem identifier 161591
SMILES CN(C([C@]35N1[C@@]2([H])NC4=C(C=CC=C4)[C@]([C@@]68C(C=CC=C9)=C9N[C@@]([H])6N7[C@@](C8)%10C(N(C)[C@@](CO)(SS%10)C7=O)=O)2C3)=O)[C@@](CO)(SS5)C1=O
InChiKey PZPPOCZWRGNKIR-UHFFFAOYSA-N

References for Chaetocin

References are publications that support the biological activity of the product
  • Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism.

    Dixit D et al (2014) Cell Death Dis 5 : e1212.
  • Reply to 'Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases'.

    Greiner D et al (2013) Nat Chem Biol 9(3) : 137
  • Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

    Cherblanc FL et al (2013) Nat Chem Biol 9(3) : 136-7.
  • The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation.

    Isham CR et al (2012) Br J Cancer 106(2) : 314-23.

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