Chelerythrine Chloride

(HB0190)

Product overview

  • Name
    Chelerythrine Chloride
  • Short description
    PKC inhibitor
  • Biological description
    Protein kinase C (PKC) inhibitor (IC50 = 660 nM). Competitive inhibitor of the phosphate acceptor, non-competitive ATP inhibitor. Inhibits BclXL function; inhibits BclXL-Bak BH3 peptide binding (IC50 = 1.5 μM). Shows apoptotic and antitumor actions.
  • Alternative names
    CHE
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
  • Molecular Weight
    383.83
  • Chemical structure
    Chelerythrine Chloride  [3895-92-9]
  • Molecular Formula
    C21H18ClNO4
  • CAS Number
    3895-92-9
  • PubChem identifier
    72311
  • SMILES
    C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.Cl

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in water (10mM) or DMSO (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Chelerythrine Chloride

  • Chelerythrine is a potent and specific inhibitor of protein kinase C.

    Herbert JM et al (1990) Biochem Biophys Res Commun 172(3) : 993-9.
    PubMedID: 2244923
  • Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell.

    Zhang ZF et al (2011) Arch Pharm Res 34(5) : 791-800.
    PubMedID: 21656365
  • Identification of chelerythrine as an inhibitor of BclXL function.

    Chan SL et al (2003) J Biol Chem 278(23) : 20453-6.
    PubMedID: 12702731

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