Chromanol 293B

(HB0988)

Product overview

  • Name
    Chromanol 293B
  • Short description
    Kv7.1 channel blocker
  • Biological description
    Kv7.1 channel blocker (also known as the slow delayed rectifier or IKs channel). Blocks the K+ current (IC50 = 1.8 µM). Selective for the KCNQ1 subunit combined with KCNE3 over KCNE1 (IC50 values are 0.54 and 15.1 µM respectively). Also blocks the CFTR chloride current (ICFTR) and Kv4.3 channel Ito transient outward current (IC50 values are 19 and 38 µM respectively).
  • Biological action
    Blocker
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
  • Molecular Weight
    324.39
  • Chemical structure
    Chromanol 293B  [163163-23-3]
  • Molecular Formula
    C15H20N2O4S
  • CAS Number
    163163-23-3

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in ethanol (20mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Chromanol 293B

  • Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKs), inhibits the CFTR Cl- current.

    Bachmann A et al (2001) Naunyn Schmiedebergs Arch Pharmacol 363(6) : 590-6.
    PubMedID: 11414653
  • Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes.

    Sun ZQ et al (2001) J Cardiovasc Electrophysiol 12(4) : 472-8.
    PubMedID: 11332571
  • Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel.

    Bett GC et al (2006) J Physiol 576(Pt 3) : 755-67.
    PubMedID: 16887873

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