CI 994

(HB1385)

Product overview

  • Name
    CI 994
  • Short description
    Potent, selective HDAC inhibitor
  • Biological description
    Potent and selective histone deacetylase (HDAC) inhibitor. Inhibits HDAC1, 3, 6 and 8 (IC50 values are 0.41, 0.75, >100 and >100 µM respectively). Induces histone H3 hyperacetylation and cell differentiation. Shows anti-proliferative and apoptotic actions. Cell-permeable.
  • Alternative names
    CI-994
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    4-(Acetylamino)-N-(2-aminophenyl)be nzamide
  • Molecular Weight
    269.3
  • Chemical structure
    CI 994  [112522-64-2]
  • Molecular Formula
    C15H15N3O2
  • CAS Number
    112522-64-2

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CI 994

  • Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group.

    Beckers T et al (2007) Int J Cancer 121(5) : 1138-48.
    PubMedID: 17455259
  • Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma.

    Kraker AJ et al (2003) Mol Cancer Ther 2(4) : 401-8.
    PubMedID: 12700284
  • In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines.

    Loprevite M et al (2005) Oncol Res 15(1) : 39-48.
    PubMedID: 15839304

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