Product overview

Name CI 994
Alternative names CI-994
Purity >99%
Description Potent, selective HDAC inhibitor
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Biological Data

Biological description Potent and selective histone deacetylase (HDAC) inhibitor. Inhibits HDAC1, 3, 6 and 8 (IC50 values are 0.41, 0.75, >100 and >100 µM respectively). Induces histone H3 hyperacetylation and cell differentiation. Shows anti-proliferative and apoptotic actions. Cell-permeable.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >99%
Chemical name 4-(Acetylamino)-N-(2-aminophenyl)be nzamide
Molecular Weight 269.3
Chemical structure CI 994  [112522-64-2] Chemical Structure
Molecular Formula C15H15N3O2
CAS Number 112522-64-2
PubChem identifier 2746
SMILES O=C(NC2=C(N)C=CC=C2)C1=CC=C(NC(C)=O)C=C1
InChiKey VAZAPHZUAVEOMC-UHFFFAOYSA-N

References for CI 994

References are publications that support the biological activity of the product
  • Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group.

    Beckers T et al (2007) Int J Cancer 121(5) : 1138-48.
  • In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines.

    Loprevite M et al (2005) Oncol Res 15(1) : 39-48.
  • Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma.

    Kraker AJ et al (2003) Mol Cancer Ther 2(4) : 401-8.

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