Product overview

Name Cilnidipine
Alternative names FRC 8653
Purity >99%
Description Potent L- / N-type calcium channel blocker
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Biological Data

Biological description Potent L- and N-type calcium channel blocker (IC50 values are 100 and 200 nM). Inhibits sympathetic neurotransmitter release via N-type Ca2+ channel block. Shows antihypertensive, cardioprotective, renoprotective and neuroprotective actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl(2E)-3-phenyl-2-propenyl ester
Molecular Weight 492.52
Chemical structure Cilnidipine  [132203-70-4] Chemical Structure
Molecular Formula C27H28N2O7
CAS Number 132203-70-4
PubChem identifier 2752
SMILES COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OCC=CC1=CC=CC=C1
InChiKey KJEBULYHNRNJTE-UHFFFAOYSA-N

References for Cilnidipine

References are publications that support the biological activity of the product
  • Cilnidipine: a new generation Ca channel blocker with inhibitory action on sympathetic neurotransmitter release.

    Takahara A (2009) Cardiovasc Ther 27(2) : 124-39.
  • Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model.

    Takahara A et al (2004) Biol Pharm Bull 27(9) : 1388-91.
  • Effect of cilnidipine, a novel dihydropyridine Ca++-channel antagonist, on N-type Ca++ channel in rat dorsal root ganglion neurons.

    Fujii S et al (1997) J Pharmacol Exp Ther 280(3) : 1184-91.

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