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Cinnabarinic acid


Product overview

  • Name
    Cinnabarinic acid
  • Short description
    Selective mGlu4 agonist
  • Biological description
    Selective mGlu4 receptor agonist. Endogenous metabolite of the kynurenine pathway. Shows no activity at other mGlu receptors. Protective against EAE, a multiple sclerosis model in mice.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
  • Molecular Weight
  • Chemical structure
    Cinnabarinic acid  [606-59-7]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Cinnabarinic acid

  • Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors.

    Fazio F et al (2012) Mol Pharmacol 81(5) : 643-56.
    PubMedID: 22311707
  • An expanding range of targets for kynurenine metabolites of tryptophan.

    Stone TW et al (2013) Trends Pharmacol Sci 34(2) : 136-43.
    PubMedID: 23123095
  • Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice.

    Fazio F et al (2014) Neuropharmacology 81 : 237-43.
    PubMedID: 24565643
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