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Data

Product overview

  • Name
    CIQ
  • Short description
    GluN2C / GluN2D subunit selective NMDA receptor positive allosteric modulator
  • Biological description
    GluN2C / GluN2D subunit selective NMDA receptor positive allosteric modulator. Causes two-fold increase in receptor channel opening frequency (EC50 values are 2.7 and 2.8 µM for GluN2C and GluN2D respectively). Reduces associated behaviours in schizophrenia models and potentially enhances dopamine release in Parkinson's disease models.
  • Biological action
    PAM
  • Purity
    >98%
  • Customer comments

    We were happy with the CIQ indeed. Verified customer, University of Milan

  • Citations

Images

Properties

  • Chemical name
    (3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
  • Molecular Weight
    467.94
  • Chemical structure
    CIQ  [486427-17-2]
  • Molecular Formula
    C26H26ClNO5
  • CAS Number
    486427-17-2
  • PubChem identifier
    4231127
  • SMILES
    COC1=CC=C(C=C1)OCC2C3=CC(=C(C=C3CCN2C(=O)C4=CC(=CC=C4)Cl)OC)OC
  • InChi
    InChI=1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
  • InChiKey
    VYMILMYEENZHAR-UHFFFAOYSA-N

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100mM) and in ethanol (10mM, sonication)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CIQ

  • A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.

    Mullasseril P et al (2010) Nat Commun 1 : 90
    PubMedID: 20981015
  • GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice.

    Suryavanshi PS et al (2014) Br J Pharmacol 171(3) : 799-809.
    PubMedID: 24236947
  • Allosteric modulation of GluN2C/GluN2D-containing NMDA receptors bidirectionally modulates dopamine release: implication for Parkinson's disease.

    Zhang X et al (2014) Br J Pharmacol 171(16) : 3938-45.
    PubMedID: 24818560
Support & Resources

Reviews

  • Verified customer, University of Milan

    We were happy with the CIQ indeed.