Cisplatin

(HB1289)

Product overview

  • Name
    Cisplatin
  • Short description
    Potent antitumour agent
  • Biological description
    Potent antitumour agent. Induces apoptosis by arresting cell cycle at G2 phase and caspase 3 activation. Induces interstrand and intrastrand DNA adducts. Displays anticancer properties.
  • Biological action
    Other
  • Our products in action

Properties

  • Chemical name
    cis-Diaminodichloroplatinum
  • Molecular Weight
    300.05
  • Molecular Formula
    Cl2H6N2Pt
  • CAS Number
    15663-27-1

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in water (5mM, gentle warming)

References for Cisplatin

  • Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma.

    Seki K et al (2000) Cancer Chemother Pharmacol 45(3) : 199-206.
    PubMedID: 10663637
  • Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin.

    van Waardenburg RC et al (2004) J Biol Chem 279(52) : 54502-9.
    PubMedID: 15471886
  • Biomolecular targets for platinum antitumor drugs.

    Bose RN (2002) Mini Rev Med Chem 2(2) : 103-11.
    PubMedID: 12370072
  • Cisplatin: mode of cytotoxic action and molecular basis of resistance.

    Siddik ZH (2003) Oncogene 22(47) : 7265-79.
    PubMedID: 14576837

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