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Citalopram hydrobromide

(HB2142)
Data

Product overview

  • Name
    Citalopram hydrobromide
  • Short description
    Potent, selective 5-HT uptake inhibitor
  • Biological description
    Potent, selective 5-HT uptake inhibitor (Ki = 0.75 nM at rSERT and IC50 values are 1.8, ~8,000 and ~40,000 nM for 5-HT, noradrenaline and dopamine uptake respectively). Shows antidepressant effects. Active in vivo.
  • Alternative names
    Lu 10-171
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitril e hydrobromide
  • Molecular Weight
    405.31
  • Chemical structure
    Citalopram hydrobromide
  • Molecular Formula
    C20H21FN2O.HBr
  • CAS Number
    59729-32-7
  • PubChem identifier
    77995
  • SMILES
    CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.Br
  • InChi
    InChI=1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
  • InChiKey
    WIHMBLDNRMIGDW-UHFFFAOYSA-N
  • MDL number
    MFCD02101306
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room Temperature
  • Solubility overview
    Soluble in ethanol (50 mM) and in water (10 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Citalopram hydrobromide

  • Citalopram--pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity.

    Hyttel J (1982) Prog Neuropsychopharmacol Biol Psychiatry 6(3) : 277-95.
    PubMedID: 6128769
  • Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.

    Owens MJ et al (1997) J Pharmacol Exp Ther 283(3) : 1305-22.
    PubMedID: 9400006
  • Preclinical pharmacology of citalopram.

    Popik P (1999) J Clin Psychopharmacol 19(5 Suppl 1) : 4S-22S.
    PubMedID: 10507505
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