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clasto-Lactacystin β-lactone

(HB3842)
Data

Product overview

  • Name
    clasto-Lactacystin β-lactone
  • Short description
    Potent, selective and irreversible proteasome inhibitor
  • Biological description
    Potent and selective irreversible and cell permeable proteasome inhibitor. Inhibits the chymotrypsin-like, trypsin-like and caspase-like peptidase activity of the proteasome. The active metabolite of lactacystin with higher potency since it does not require hydrolysis in order to become cell permeable. Calpain and cathepsin inhibitor. Apoptosis inducer. Anticancer compound. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Induces neuritogenesis. Autophagy inducer.
  • Purity
    >95%
  • Citations

Properties

  • Molecular Weight
    213.2
  • CAS Number
    154226-60-5
  • InChiKey
    FWPWHHUJACGNMZ-OEUIFBLYSA-N
  • Appearance
    White to off-white solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (75mM) and in water (10mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
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