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Product overview

  • Name
  • Short description
    Potent, selective PKA inhibitor
  • Biological description
    Potent and selective protein kinase A (PKA) inhibitor (IC50 = 30 nM ). Membrane permeable. Blocks ATP-binding site of PKA. Restores morphine-related behaviours in morphine tolerance.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    PKA Inhibitor XI
  • Molecular Weight
  • Chemical structure
    CMIQ  [161468-32-2]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Solubility overview
    Soluble in DMSO (50mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CMIQ

  • PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice.

    Smith FL et al (2006) Pharmacol Res 54(6) : 474-80.
    PubMedID: 17056270
  • Selective inhibition of cyclic AMP-dependent protein kinase by isoquinoline derivatives.

    Lu ZX et al (1996) Biol Chem Hoppe Seyler 377(6) : 373-84.
    PubMedID: 8839983
  • Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.

    Hucho TB et al (2005) J Neurosci 25(26) : 6119-26.
    PubMedID: 15987941
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