Product overview

  • Name
    Co 102862
  • Short description
    Potent voltage-gated Na+ channel blocker
  • Biological description
    Potent voltage-gated Na+ channel blocker. Shows greater affinity for inactive (Ki = 0.4 µM) compared to resting state Nav1.2 channels (Kr = 30 µM). Shows anticonvulsant and potential analgesic actions.
  • Biological action
    Blocker
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide
  • Molecular Weight
    273.26
  • Chemical structure
    Co 102862  [181144-66-1]
  • Molecular Formula
    C14H12FN3O2
  • CAS Number
    181144-66-1

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)

References for Co 102862

  • V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels.

    Ilyin VI et al (2005) Br J Pharmacol 144(6) : 801-12.
    PubMedID: 15778702
  • Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states.

    Ilyin VI et al (2006) J Pharmacol Exp Ther 318(3) : 1083-93.
    PubMedID: 16728593
  • Functional and pharmacological properties of human and rat NaV1.8 channels.

    Browne LE et al (2009) Neuropharmacology 56(5) : 905-14.
    PubMedID: 19371587

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