Product overview

Name Co 102862
Alternative names V102862
Purity >99%
Description Potent voltage-gated Na+ channel blocker
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Biological Data

Biological description Potent voltage-gated Na+ channel blocker. Shows greater affinity for inactive (Ki = 0.4 µM) compared to resting state Nav1.2 channels (Kr = 30 µM). Shows anticonvulsant and potential analgesic actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >99%
Chemical name 2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide
Molecular Weight 273.26
Chemical structure Co 102862  [181144-66-1] Chemical Structure
Molecular Formula C14H12FN3O2
CAS Number 181144-66-1
PubChem identifier 9816959
SMILES NC(=O)N\N=C\C1=CC=C(OC2=CC=C(F)C=C2)C=C1
InChiKey MHUUDVZSPFRUSK-RQZCQDPDSA-N

References for Co 102862

References are publications that support the biological activity of the product
  • Functional and pharmacological properties of human and rat NaV1.8 channels.

    Browne LE et al (2009) Neuropharmacology 56(5) : 905-14.
  • Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states.

    Ilyin VI et al (2006) J Pharmacol Exp Ther 318(3) : 1083-93.
  • V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels.

    Ilyin VI et al (2005) Br J Pharmacol 144(6) : 801-12.

3 Item(s)