Corticosterone

(HB2808)

Product overview

  • Name
    Corticosterone
  • Short description
    Endogenous gluococorticoid. MR and GR agonist.
  • Biological description
    Endogenous gluococorticoid. Acts as a mineralcorticoid (MR) and glucocorticoid receptor (GR) agonist. Involved in a wide range of biological processes and shows a variety of effects.
  • Biological action
    Agonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    (11β)-11,21-Dihydroxypregn-4-ene-3,2 0-dione
  • Molecular Weight
    346.46
  • Chemical structure
    Corticosterone [50-22-6]
  • Molecular Formula
    C21H30O4
  • CAS Number
    50-22-6
  • PubChem identifier
    5753
  • SMILES
    C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O
  • InChi
    InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
  • InChiKey
    OMFXVFTZEKFJBZ-HJTSIMOOSA-N
  • MDL number
    MFCD00037715

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100 mM) and in ethanol (10 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Corticosterone

  • Hippocampal corticosterone impairs memory consolidation during sleep but improves consolidation in the wake state.

    Kelemen E et al (2014) Hippocampus 24(5) : 510-5.
    PubMedID: 24596244
  • Corticosterone rapidly increases thorns of CA3 neurons via synaptic/extranuclear glucocorticoid receptor in rat hippocampus.

    Yoshiya M et al (2013) Front Neural Circuits 7 : 191
    PubMedID: 24348341
  • Corticosterone acts in the nucleus accumbens to enhance dopamine signaling and potentiate reinstatement of cocaine seeking.

    Graf EN et al (2013) J Neurosci 33(29) : 11800-10.
    PubMedID: 23864669

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