CP 690550 citrate

(HB1427)

Product overview

  • Name
    CP 690550 citrate
  • Short description
    Potent JAK inhibitor
  • Biological description
    Potent JAK inhibitor. Inhibits JAK3, JAK2 and JAK1 (IC50 values are 1, 20 and 112 nM respectively). Reduces pro-inflammatory cytokine release. Shows immunosuppressant actions.
  • Alternative names
    Tofacitinib citrate
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    (3R,4R)-4-Methyl-3-(methyl-7H-pyrro lo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepro panenitrile citrate
  • Molecular Weight
    504.49
  • Chemical structure
    CP 690550 citrate  [540737-29-9]
  • Molecular Formula
    C16H20N6O.C6H8O7
  • CAS Number
    540737-29-9

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CP 690550 citrate

  • Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550).

    Jiang JK et al (2008) J Med Chem 51(24) : 8012-8.
    PubMedID: 19053756
  • CP-690550 Treatment Ameliorates Established Disease and Provides Long-Term Therapeutic Effects in an SKG Arthritis Model.

    Oh K et al (2013) Immune Netw 13(6) : 257-63.
    PubMedID: 24385944
  • Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.

    Flanagan ME et al (2010) J Med Chem 53(24) : 8468-84.
    PubMedID: 21105711

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