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CP-91149

(HB0215)
Data

Product overview

  • Name
    CP-91149
  • Short description
    Synthetic GP inhibitor
  • Biological description
    Synthetic glycogen phosphorylase (GP) inhibitor (IC50 = 0.5 µM). Approx 5-to 10- fold less potent in the absence of glucose. Also inhibits glucagon-stimulated glycogenolysis (IC50 = 2.1 µM) and activates glycogen synthase. Displays growth inhibitory properties.
  • Alternative names
    CP-91,149
  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    5-Chloro-N-[(1S,2R)-3-(dimethylamino)-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide
  • Molecular Weight
    399.87
  • Chemical structure
    CP-91149  [186392-40-5]
  • Molecular Formula
    C21H22ClN3O3
  • CAS Number
    186392-40-5

Storing and Using Your Product

  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CP-91149

  • Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression.

    Schnier JB et al (2003) Biochem Biophys Res Commun 309(1) : 126-34.
    PubMedID: 12943673
  • Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.

    Martin WH et al (1998) Proc Natl Acad Sci U S A 95(4) : 1776-81.
    PubMedID: 9465093
  • Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis.

    Aiston S et al (2001) J Biol Chem 276(26) : 23858-66.
    PubMedID: 11309391
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