Product overview

Name CP-91149
Alternative names CP-91,149
Description Synthetic GP inhibitor
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Biological Data

Biological description Synthetic glycogen phosphorylase (GP) inhibitor (IC50 = 0.5 µM). Approx 5-to 10- fold less potent in the absence of glucose. Also inhibits glucagon-stimulated glycogenolysis (IC50 = 2.1 µM) and activates glycogen synthase. Displays growth inhibitory properties.

Solubility & Handling

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 5-Chloro-N-[(1S,2R)-3-(dimethylamino)-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide
Molecular Weight 399.87
Chemical structure CP-91149  [186392-40-5] Chemical Structure
Molecular Formula C21H22ClN3O3
CAS Number 186392-40-5

References for CP-91149

References are publications that support the biological activity of the product
  • Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression.

    Schnier JB et al (2003) Biochem Biophys Res Commun 309(1) : 126-34.
  • Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis.

    Aiston S et al (2001) J Biol Chem 276(26) : 23858-66.
  • Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.

    Martin WH et al (1998) Proc Natl Acad Sci U S A 95(4) : 1776-81.

3 Item(s)