In my cart

You have no items in your shopping cart.

Data

Product overview

  • Name
    CPCCOEt
  • Short description
    Selective, non-competitive mGlu1 antagonist
  • Biological description
    Selective and non-competitive mGlu1 receptor antagonist (IC50 = 6.5 µM). Displays no agonist or antagonist activity at mGlu2, 4a, 5a, 7b and 8a or iGlu receptors at concentrations up to 100µM. Prevents rebound potentiation.
  • Biological action
    Antagonist
  • Purity
    >99%
  • Citations

Properties

  • Chemical name
    7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester
  • Molecular Weight
    247.25
  • Chemical structure
    CPCCOEt  [179067-99-3]
  • Molecular Formula
    C13H13NO4
  • CAS Number
    179067-99-3
  • PubChem identifier
    6278000
  • SMILES
    CCOC(=O)C12CC1/C(=N\O)/C3=CC=CC=C3O2
  • Source
    Synthetic
  • InChi
    InChI=1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-
  • InChiKey
    FXCTZFMSAHZQTR-KAMYIIQDSA-N
  • MDL number
    MFCD00947859
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CPCCOEt

  • CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.

    Litschig S et al (1999) Mol Pharmacol 55(3) : 453-61.
    PubMedID: 10051528
  • Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor.

    Hermans E et al (1998) Neuropharmacology 37(12) : 1645-7.
    PubMedID: 9886688
  • mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron.

    Sugiyama Y et al (2008) Eur J Neurosci 27(4) : 884-96.
    PubMedID: 18279362
Our products in action
The following papers have cited the use of CPCCOEt (HB0216) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • Phenotypic characterization of Grm1crv4 mice reveals a functional role for the type 1 metabotropic glutamate receptor in bone mineralization.

    Musante et al(2017) Bone. 94 : 114-123
    PubMedID: 27989650
Support & Resources