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Data

Product overview

  • Name
    CPPG
  • Short description
    Potent group III mGluR antagonist
  • Biological description
    Potent mGlu receptor antagonist. Shows 20-fold selectivity for group III compared to group II mGlu receptors (IC50 values are 2.2 and 46.3 nM respectively). Less potent antagonist at group I mGlu receptors.
  • Biological action
    Antagonist
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    (RS)-α-Cyclopropyl-4-phosphonophenyl glycine
  • Molecular Weight
    271.21
  • Chemical structure
    CPPG  [183364-82-1]
  • Molecular Formula
    C11H14NO5P
  • CAS Number
    183364-82-1

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in NaOH(aq) (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CPPG

  • The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist.

    Toms NJ et al (1996) Br J Pharmacol 119(5) : 851-4.
    PubMedID: 8922731
  • Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord.

    Jane DE et al (1996) Neuropharmacology 35(8) : 1029-35.
    PubMedID: 9121605
  • Antagonism of metabotropic glutamate receptor 4 receptors by (RS)-alpha-cyclopropyl-4-phosphonophenylglycine alters the taste of amino acids in rats.

    Eschle BK et al (2009) Neuroscience 163(4) : 1292-301.
    PubMedID: 19631258
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