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Cyclosporin A


Product overview

  • Name
    Cyclosporin A
  • Short description
    Potent calcineurin inhibitor. Inhibits MPTP opening.
  • Biological description
    Potent calcineurin inhibitor (IC50 = 5 nM). Inhibits mitochondrial permeability transition pore (MPTP) opening and also P-glycoprotein inhibitor and increases AKT activation. Displays immunosuppressive, tumor promoting and pro-angiogenic properties.
  • Alternative names
    Cyclosporine; Antibiotic S 7481F1; Ciclosporin A; CSA; cyclosporine A
  • Biological action
  • Purity
  • Citations


  • Molecular Weight
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • InChiKey

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM) or ethanol (50mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Cyclosporin A

  • Cyclosporin A Promotes Tumor Angiogenesis in a Calcineurin-Independent Manner by Increasing Mitochondrial Reactive Oxygen Species.

    Zhou AY et al (2014) Mol Cancer Res :
    PubMedID: 25009293
  • The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram.

    O'Brien FE et al (2014) Behav Brain Res 261 : 17-25.
    PubMedID: 24280122
  • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

    Fruman DA et al (1992) Proc Natl Acad Sci U S A 89(9) : 3686-90.
    PubMedID: 1373887
  • Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis.

    Han W et al (2010) J Biol Chem 285(15) : 11369-77.
    PubMedID: 20154081
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