Cyclosporin A

(HB0220)

Product overview

  • Name
    Cyclosporin A
  • Short description
    Potent calcineurin inhibitor. Inhibits MPTP opening.
  • Biological description
    Potent calcineurin inhibitor (IC50 = 5 nM). Inhibits mitochondrial permeability transition pore (MPTP) opening and also P-glycoprotein inhibitor and increases AKT activation. Displays immunosuppressive, tumor promoting and pro-angiogenic properties.
  • Alternative names
    Cyclosporine; Antibiotic S 7481F1; Ciclosporin A; CSA; cyclosporine A
  • Biological action
    Inhibitor
  • Purity
    >99%
  • Our products in action

Properties

  • Molecular Weight
    1202.63
  • Molecular Formula
    C62H111N11O12
  • CAS Number
    59865-13-3

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    soluble in DMSO (100mM) or ethanol (50mM)

References for Cyclosporin A

  • Cyclosporin A Promotes Tumor Angiogenesis in a Calcineurin-Independent Manner by Increasing Mitochondrial Reactive Oxygen Species.

    Zhou AY et al (2014) Mol Cancer Res :
    PubMedID: 25009293
  • The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram.

    O'Brien FE et al (2014) Behav Brain Res 261 : 17-25.
    PubMedID: 24280122
  • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

    Fruman DA et al (1992) Proc Natl Acad Sci U S A 89(9) : 3686-90.
    PubMedID: 1373887
  • Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis.

    Han W et al (2010) J Biol Chem 285(15) : 11369-77.
    PubMedID: 20154081

Reviews & Product Guides