Cypermethrin

(HB0222)

Product overview

  • Name
    Cypermethrin
  • Short description
    Potent PP2B inhibitor
  • Biological description
    Potent phosphatase 2B (PP2B) inhibitor (IC50 = 40 pM). Type II synthetic pyrethroid insecticide. Interacts with sodium channels producing neurotoxin effects. Also potent calcineurin inhibitor (IC50 = 100 nM). Blood brain barrier permeable.
  • Biological action
    Inhibitor
  • Purity
    >96%
  • Citations

Properties

  • Molecular Weight
    416.3
  • Chemical structure
    Cypermethrin  [52315-07-8]
  • Molecular Formula
    C22H19Cl2NO3
  • CAS Number
    52315-07-8
  • PubChem identifier
    2912
  • SMILES
    CC1(C)C(\C=C(/Cl)Cl)C1C(=O)OC(C#N)C1=CC(OC2=CC=CC=C2)=CC=C1

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    soluble in ethanol (25mg/ml) or DMSO
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Cypermethrin

  • Inhibition of phosphatase 2B prevents expression of hippocampal long-term potentiation.

    Wang JH et al (1994) Neuroreport 5(17) : 2377-80.
    PubMedID: 7881062
  • Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides.

    Enan E et al (1992) Biochem Pharmacol 43(8) : 1777-84.
    PubMedID: 1315545
  • Effect of cypermethrin on memory, movement activity and coordination in mice after transient incomplete cerebral ischemia.

    Nieradko-Iwanicka B et al (2008) Pharmacol Rep 60(5) : 699-705.
    PubMedID: 19066417
  • Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides.

    Enan E et al (1992) Biochem Pharmacol 43(8) : 1777-84.
    PubMedID: 1315545

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