Product overview

  • Name
    CyPPA
  • Short description
    Selective KCa2.2 / KCa2.3 activator
  • Biological description
    Selective KCa2.2 and KCa2.3 activator (EC50 values are 14 and 5.6 µM respectively). Displays little or no activity at KCa2.1 and KCa3.1 channels. Reduces dopaminergic neuron activity and inhibits dopamine release.
  • Biological action
    Activator
  • Purity
    >99%
  • Our products in action

Properties

  • Chemical name
    N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine
  • Molecular Weight
    285.39
  • Chemical structure
    CyPPA  [73029-73-9]
  • Molecular Formula
    C16H23N5
  • CAS Number
    73029-73-9

Storing and Using Your Product

  • Storage instructions
    +4°C

References for CyPPA

  • Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels.

    Hougaard C et al (2007) Br J Pharmacol 151(5) : 655-65.
    PubMedID: 17486140
  • New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.

    Coleman N et al (2014) Mol Pharmacol 86(3) : 342-57.
    PubMedID: 24958817
  • CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate.

    Herrik KF et al (2012) Front Pharmacol 3 : 11
    PubMedID: 22347859

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