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Product overview

  • Name
  • Short description
    Selective KCa2.2 / KCa2.3 activator
  • Biological description
    Selective KCa2.2 and KCa2.3 activator (EC50 values are 14 and 5.6 µM respectively). Displays little or no activity at KCa2.1 and KCa3.1 channels. Reduces dopaminergic neuron activity and inhibits dopamine release.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    CyPPA  [73029-73-9]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for CyPPA

  • Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels.

    Hougaard C et al (2007) Br J Pharmacol 151(5) : 655-65.
    PubMedID: 17486140
  • New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.

    Coleman N et al (2014) Mol Pharmacol 86(3) : 342-57.
    PubMedID: 24958817
  • CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate.

    Herrik KF et al (2012) Front Pharmacol 3 : 11
    PubMedID: 22347859
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