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Cystamine dihydrochloride

(HB0870)
Data

Product overview

  • Name
    Cystamine dihydrochloride
  • Short description
    Transglutaminase inhibitor
  • Biological description
    Transglutaminase inhibitor. Shows neuroprotective actions and acts as an antioxidant. Shows actions against Huntington's disease.
  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    2,2'-Diaminodiethyl disulfide dihydrochloride
  • Molecular Weight
    225.2
  • Chemical structure
    Cystamine dihydrochloride  [56-17-7]
  • Molecular Formula
    C4H12N2S2.2HCl
  • CAS Number
    56-17-7

Storing and Using Your Product

  • Storage instructions
    room temperature (desiccate)
  • Solubility overview
    soluble in water (100mM) or DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Cystamine dihydrochloride

  • Therapeutic effects of cystamine in a murine model of Huntington's disease.

    Dedeoglu A et al (2002) J Neurosci 22(20) : 8942-50.
    PubMedID: 12388601
  • Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.

    Borrell-Pagès M et al (2006) J Clin Invest 116(5) : 1410-24.
    PubMedID: 16604191
  • Oxidizing effects of exogenous stressors in Huntington's disease knock-in striatal cells--protective effect of cystamine and creatine.

    Ribeiro M et al (2013) Toxicol Sci 136(2) : 487-99.
    PubMedID: 24008831
  • Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells.

    Mao Z et al (2006) Eur J Neurosci 23(7) : 1701-10.
    PubMedID: 16623826
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