D-erythro-N,N-Dimethylsphingosine

(HB0237)

Product overview

  • Name
    D-erythro-N,N-Dimethylsphingosine
  • Short description
    Sphingosine kinase inhibitor
  • Biological description
    Competitive sphingosine kinase inhibitor (IC50 = 5 µM). Also inhibits protein kinase C (PKC). Shows cardioprotective, apoptotic and anti-cancer actions.
  • Alternative names
    DMS
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Our products in action

Properties

  • Molecular Weight
    327.5
  • Chemical structure
    D-erythro-N,N-Dimethylsphingosine  [119567-63-4]
  • Molecular Formula
    C20H41NO2
  • CAS Number
    119567-63-4

Storing and Using Your Product

  • Solubility overview
    soluble in ethanol (25mg/ml) or DMSO (25mg/ml)

References for D-erythro-N,N-Dimethylsphingosine

  • Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.

    Jin ZQ et al (2006) Cardiovasc Res 71(4) : 725-34.
    PubMedID: 16831409
  • Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines.

    Sweeney EA et al (1996) Int J Cancer 66(3) : 358-66.
    PubMedID: 8621258
  • D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells.

    Xu CB et al (2002) Atherosclerosis 164(2) : 237-43.
    PubMedID: 12204793
  • Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities.

    Igarashi Y et al (1989) Biochemistry 28(17) : 6796-800.
    PubMedID: 2479412

Reviews & Product Guides