D-erythro-N,N-Dimethylsphingosine

(HB0237)
Technical documents: Datasheet

Product overview

Name D-erythro-N,N-Dimethylsphingosine
Alternative names DMS
Purity >98%
Description Sphingosine kinase inhibitor
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Biological Data

Biological description Competitive sphingosine kinase inhibitor (IC50 = 5 µM). Also inhibits protein kinase C (PKC). Shows cardioprotective, apoptotic and anti-cancer actions.

Solubility & Handling

Solubility overview Soluble in ethanol (25mg/ml) or DMSO (25mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Molecular Weight 327.5
Chemical structure D-erythro-N,N-Dimethylsphingosine  [119567-63-4] Chemical Structure
Molecular Formula C20H41NO2
CAS Number 119567-63-4
SMILES CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)N(C)C

References for D-erythro-N,N-Dimethylsphingosine

References are publications that support the biological activity of the product
  • Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.

    Jin ZQ et al (2006) Cardiovasc Res 71(4) : 725-34.
  • D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells.

    Xu CB et al (2002) Atherosclerosis 164(2) : 237-43.
  • Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines.

    Sweeney EA et al (1996) Int J Cancer 66(3) : 358-66.
  • Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities.

    Igarashi Y et al (1989) Biochemistry 28(17) : 6796-800.

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