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Data

Product overview

  • Name
    DAMGO
  • Short description
    Potent, selective μ-opioid receptor agonist
  • Biological description
    Potent, selective μ-opioid receptor agonist (Ki values are 2.0 and >1000 nM at μ, κ and δ respectively). Shows antinociceptive activity.
  • Alternative names
    DAGO
  • Biological action
    Agonist
  • Citations

Properties

  • Chemical name
    H-Tyr-D-Ala-Gly-N(Me)Phe-Gly-ol
  • Molecular Weight
    513.7
  • Molecular Formula
    C26H35N5O6
  • CAS Number
    78123-71-4
  • PubChem identifier
    5462471
  • SMILES
    C[C@H](C(=O)NCC(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)NCCO)NC(=O)[C@H](CC2=CC=C(C=C2)O)N
  • InChi
    InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
  • InChiKey
    HPZJMUBDEAMBFI-WTNAPCKOSA-N
  • MDL number
    MFCD00133215

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in water (4 mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for DAMGO

  • Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.

    Raynor et al (1994) Mol Pharmacol 45(2) : 330-4
    PubMedID: 8114680
  • The μ-opioid receptor agonist DAMGO presynaptically suppresses solitary tract-evoked input to neurons in the rostral solitary nucleus.

    Boxwell et al (2013) J Neurophysiol 109(11) : 2815-26
    PubMedID: 23486207
  • DAMGO in the central amygdala alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia.

    Zhang et al (2013) Neuroscience 252 : 359-66
    PubMedID: 23994597
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