Daphnetin

(HB0229)

Product overview

  • Name
    Daphnetin
  • Short description
    Protein kinase inhibitor
  • Biological description
    Protein kinase inhibitor (IC50 values are 7.67, 9.33 and 25.01 µM at EGFR, PKA and PKC respectively). Cell-permeable, coumarin derivative. Shows antioxidant and antimalarial actions.
  • Biological action
    Inhibitor
  • Purity
    >97%
  • Our products in action

Properties

  • Chemical name
    7,8-Dihydroxycoumarin
  • Molecular Weight
    178.14
  • Chemical structure
    Daphnetin  [486-35-1]
  • Molecular Formula
    C9H6O4
  • CAS Number
    486-35-1
  • PubChem identifier
    5280569
  • SMILES
    C1=CC(=C(C2=C1C=CC(=O)O2)O)O

Storing and Using Your Product

  • Solubility overview
    soluble in DMSO or EtOH

References for Daphnetin

  • Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor.

    Yang EB et al (1999) Biochem Biophys Res Commun 260(3) : 682-5.
    PubMedID: 10403826
  • Daphnetin, a natural coumarin derivative, provides the neuroprotection against glutamate-induced toxicity in HT22 cells and ischemic brain injury.

    Du G et al (2014) Neurochem Res 39(2) : 269-75.
    PubMedID: 24343531
  • Daphnetin: a novel antimalarial agent with in vitro and in vivo activity.

    Yang YZ et al (1992) Am J Trop Med Hyg 46(1) : 15-20.
    PubMedID: 1311154

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