Write Your Own Review
You're reviewing:Daphnetin
Rate this item:

Images

Daphnetin product vial image | Hello Bio

Biological Data

Biological description Protein kinase inhibitor (IC50 values are 7.67, 9.33 and 25.01 µM at EGFR, PKA and PKC respectively). Cell-permeable, coumarin derivative. Shows antioxidant and antimalarial actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO or EtOH
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >97%
Chemical name 7,8-Dihydroxycoumarin
Molecular Weight 178.14
Chemical structure Daphnetin  [486-35-1] Chemical Structure
Molecular Formula C9H6O4
CAS Number 486-35-1
PubChem identifier 5280569
SMILES C1=CC(=C(C2=C1C=CC(=O)O2)O)O
InChi InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H
InChiKey ATEFPOUAMCWAQS-UHFFFAOYSA-N
MDL number MFCD00016977

References for Daphnetin

References are publications that support the biological activity of the product
  • Daphnetin, a natural coumarin derivative, provides the neuroprotection against glutamate-induced toxicity in HT22 cells and ischemic brain injury.

    Du G et al (2014) Neurochem Res 39(2) : 269-75.
  • Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor.

    Yang EB et al (1999) Biochem Biophys Res Commun 260(3) : 682-5.
  • Daphnetin: a novel antimalarial agent with in vitro and in vivo activity.

    Yang YZ et al (1992) Am J Trop Med Hyg 46(1) : 15-20.

3 Item(s)