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Data

Product overview

  • Name
    DAPT
  • Short description
    γ-secretase inhibitor. Also induces neuronal differentiation.
  • Biological description
    Cell permeable γ-secretase inhibitor. Blocks notch signaling. Reduces Aβ levels in vitro and in vivo (IC50 values are 115 and 200 nM for total β-amyloid and Aβ1-42 respectively). Enhances neuronal differentiation independent of hedgehog (Shh) signaling. Also promotes differentiation of neural stem/progenitor cells into neurons.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine tbutyl ester
  • Molecular Weight
    432.5
  • Chemical structure
    DAPT [208255-80-5]
  • CAS Number
    208255-80-5
  • InChiKey
    DWJXYEABWRJFSP-XOBRGWDASA-N
  • Appearance
    White to off-white solid

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for DAPT

  • The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins.

    Kanungo et al (2008) J Neurochem 106(5) : 2236-48
    PubMedID: 18662245
  • The notch response inhibitor DAPT enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independently of sonic hedgehog signaling.

    Crawford and Roelink (2007) Dev Dyn 236(3) : 886-92
    PubMedID: 17295317
  • Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain.

    Dovey et al (2001) J Neurochem 76(1) : 173-81
    PubMedID: 11145990
  • Lingo-1 shRNA and Notch signaling inhibitor DAPT promote differentiation of neural stem/progenitor cells into neurons.

    Wang et al (2015) Brain Res 8993(15) : 873-2
    PubMedID: 26607252
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