Daunorubicin hydrochloride

(HB4376)
Technical documents: Datasheet

Product overview

Name Daunorubicin hydrochloride
Alternative names Daunomycin
Purity >98%
Description RNA and DNA synthesis inhibitor. Antibiotic.
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Biological Data

Biological description

Antibiotic. RNA and DNA synthesis inhibitor. Inhibits topoisomerase I and II and intercalates into DNA to induce DNA damage.

Shows potent anticancer activity.

Recently investigated as part of COVID-19 compound repurposing.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride
Molecular Weight 563.99
Molecular Formula C27H29NO10.HCl
CAS Number 23541-50-6
PubChem identifier 62770
SMILES C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
InChiKey GUGHGUXZJWAIAS-QQYBVWGSSA-N
MDL number MFCD04974507
Appearance Red

References for Daunorubicin hydrochloride

References are publications that support the biological activity of the product
  • A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

    Krogan et al (2020) Nature 7816 : 459-468
  • DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

    Marchard et al (2010) Chem Biol. 17(5) : 421-33
  • Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review

    Londos-Galgiardi (1984) Biochemie 66(5) : 333-52

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