Dephostatin

(HB0236)

Product overview

  • Name
    Dephostatin
  • Short description
    Competitive PTPase inhibitor
  • Biological description
    Competitive tyrosine phosphatase (PTPase) inhibitor (IC50 = 7.7 µM). Enhances the release of amylase and intracellular calcium. Displays antibacterial and growth inhibition properties.
  • Biological action
    Inhibitor
  • Purity
    >90%
  • Our products in action

Properties

  • Chemical name
    2,5-Dihydroxy-N-methyl-N-nitrosoaniline
  • Molecular Weight
    168.15
  • Chemical structure
    Dephostatin  [151606-30-3]
  • Molecular Formula
    C7H8N2O3
  • CAS Number
    151606-30-3
  • PubChem identifier
    5353574
  • SMILES
    C1(=CC=C(C=C1N(N=O)C)O[H])O[H]

Storing and Using Your Product

  • Solubility overview
    soluble in chloroform or DMSO (22mg/ml)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Dephostatin

  • Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization.

    Imoto M et al (1993) J Antibiot (Tokyo) 46(9) : 1342-6.
    PubMedID: 8226312
  • Effect of dephostatin on intracellular free calcium concentration and amylase secretion in isolated rat pancreatic acinar cells.

    Lajas AI et al (2000) Mol Cell Biochem 205(1-2) : 163-9.
    PubMedID: 10821434
  • Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination.

    Kakeya H et al (1993) J Antibiot (Tokyo) 46(11) : 1716-9.
    PubMedID: 8270494

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