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D-erythro-Sphingosine

(HB0239)
Data

Product overview

  • Name
    D-erythro-Sphingosine
  • Short description
    PKC inhibitor
  • Biological description
    Protein kinase C (PKC) inhibitor. Also TRPM3 channel activator (EC50 = 12 µM). Exhibits little or no activity for other TRP channels. Also inhibits platelet aggregation.
  • Biological action
    Inhibitor
  • Purity
    >98%
  • Citations

Properties

  • Chemical name
    Sphingosine, C18 chain
  • Molecular Weight
    299.5
  • Molecular Formula
    C18H37NO2
  • CAS Number
    123-78-4
  • PubChem identifier
    5280335
  • SMILES
    CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO

Storing and Using Your Product

  • Solubility overview
    soluble in ethanol (25mg/ml, gentle warming) or DMSO (25mg/ml, methanol)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for D-erythro-Sphingosine

  • A concise synthesis of a promising protein kinase C inhibitor: D-erythro-sphingosine.

    Pham VT et al (2007) Arch Pharm Res 30(1) : 22-7.
    PubMedID: 17328238
  • Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected].

    Grimm C et al (2005) Mol Pharmacol 67(3) : 798-805.
    PubMedID: 15550678
  • Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets.

    Khan WA et al (1991) Biochem J 278 ( Pt 2) : 387-92.
    PubMedID: 1898331
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