Dexamethasone (water-soluble)

(HB6020)

Product overview

  • Name
    Dexamethasone (water-soluble)
  • Short description
    Synthetic glucocorticoid with potent anti-inflammatory actions. Induces hMSC differentiation. Water soluble and suitable for cell culture.
  • Biological description

    Synthetic glucocorticoid which shows potent anti-inflammatory and immunospressant effects.

    Induces differentiation of mesenchymal stem cells (hMSCs) into adipogenic, chondrogenic and osteogenic lineages.

    Commonly used with ascorbic acid and β-Gly for osteogenic differentiation of stem cells.


    This is a water soluble compound composed of a dexamethasone – Cyclodextrin complex (Approx. 65 mg dexamethasone per gm. Balance 2-hydroxypropyl-β-cyclodextrin).

    Dexamethasone free base also available.

  • Biological action
    Agonist
  • Our products in action

Properties

  • Chemical name
    (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
  • Molecular Weight
    6190.85
  • Chemical structure
    Dexamethasone water soluble [50-02-2]
  • Purity
    >98%
  • CAS Number
    50-02-2
  • PubChem identifier
    71308592
  • SMILES
    CC1CC2C3CCC4=CC(=O)C=CC4(C3C(CC2(C1C(=O)CO)C)O)C.C(C1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(O2)C(C8O)O)CO)CO)CO)CO)CO)CO)O)O)O
  • InChi
    InChI=1S/C42H70O35.C22H30O4/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71
  • InChiKey
    XEJNDGTUKUMQNG-ARJMFYCQSA-N
  • MDL number
    MFCD00064136
  • Appearance
    White to off-white solid
  • Formulation
    Approximately 65 mg dexamethasone per gm. Balance 2-hydroxypropyl-β-cyclodextrin.

Storing and Using Your Product

  • Storage instructions
    -20°C. Protect from light.
  • Solubility overview
    Soluble in water (100 mM)

References for Dexamethasone (water-soluble)

  • Dexamethasone alleviates tumor-associated brain damage and angiogenesis.

    Fan Z et al (2014) PLoS One 9(4) : e93264.
    PubMedID: 24714627
  • Glucocorticoid receptor antagonism by cyproterone acetate and RU486.

    Honer C et al (2003) Mol Pharmacol 63(5) : 1012-20.
    PubMedID: 12695529
  • Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.

    Sittichokechaiwut A et al (2010) Eur Cell Mater 20 : 45-57.
    PubMedID: 20648425