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Product overview

  • Name
  • Short description
    Selective KIR6 activator
  • Biological description
    Selective KIR6 (ATP-sensitive K+) channel activator. Increases EPSCs to around 150% of control values. Shows cardioprotective actions during ischaemic injury by activating PKCε. Also shows neuroprotective and antihypertensive actions.
  • Biological action
  • Purity
  • Citations


  • Chemical name
  • Molecular Weight
  • Chemical structure
    Diazoxide  [364-98-7]
  • Molecular Formula
  • CAS Number

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Diazoxide

  • Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons.

    Yamada KA et al (1992) J Physiol 458 : 409-23.
    PubMedID: 1302270
  • Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury.

    Kim MY et al (2006) Br J Pharmacol 149(8) : 1059-70.
    PubMedID: 17043673
  • Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives.

    Hansen JB (2006) Curr Med Chem 13(4) : 361-76.
    PubMedID: 16475928
  • The neuroprotective effect of diazoxide is mediated by mitochondrial ATP-dependent potassium channels in a rat model of acute subdural hematoma.

    Nakagawa I et al (2013) J Clin Neurosci 20(1) : 144-7.
    PubMedID: 23036174
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