Product overview

  • Name
    Diazoxide
  • Short description
    Selective KIR6 activator
  • Biological description
    Selective KIR6 (ATP-sensitive K+) channel activator. Increases EPSCs to around 150% of control values. Shows cardioprotective actions during ischaemic injury by activating PKCε. Also shows neuroprotective and antihypertensive actions.
  • Biological action
    Activator
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine1,1-dioxide
  • Molecular Weight
    230.67
  • Chemical structure
    Diazoxide  [364-98-7]
  • Molecular Formula
    C8H7ClN2O2S
  • CAS Number
    364-98-7

Storing and Using Your Product

  • Storage instructions
    room temperature
  • Solubility overview
    soluble in DMSO (100mM)

References for Diazoxide

  • Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons.

    Yamada KA et al (1992) J Physiol 458 : 409-23.
    PubMedID: 1302270
  • Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury.

    Kim MY et al (2006) Br J Pharmacol 149(8) : 1059-70.
    PubMedID: 17043673
  • Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives.

    Hansen JB (2006) Curr Med Chem 13(4) : 361-76.
    PubMedID: 16475928
  • The neuroprotective effect of diazoxide is mediated by mitochondrial ATP-dependent potassium channels in a rat model of acute subdural hematoma.

    Nakagawa I et al (2013) J Clin Neurosci 20(1) : 144-7.
    PubMedID: 23036174

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