Product overview

Name Dihydrosphingosine
Alternative names Sphinganine
Description PKC inhibitor
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Biological Data

Biological description Protein kinase C (PKC) inhibitor. Shows vasodilatory actions.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name DL-erythro-1,3-Dihydroxy-2-aminooct adecane
Molecular Weight 301.51
Chemical structure Dihydrosphingosine  [3102-56-5] Chemical Structure
Molecular Formula C18H39NO2
CAS Number 3102-56-5
PubChem identifier 5746414
SMILES OC[C@](N)([H])[C@H](O)CCCCCCCCCCCCCCC
InChiKey OTKJDMGTUTTYMP-QZTJIDSGSA-N

References for Dihydrosphingosine

References are publications that support the biological activity of the product
  • Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings.

    Hsiao SH et al (2005) Toxicol Sci 86(1) : 194-9.
  • Protein kinase C mediated anti-proliferative glucocorticoid-sphinganine synergism in cultured Pollard III prostate tumor cells.

    Sosnowski J et al (1997) J Urol 158(1) : 269-74.
  • Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60).

    Yung BY et al (1994) Biochem Biophys Res Commun 199(2) : 888-96.

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