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Disulfiram

(HB1119)
Data

Product overview

  • Name
    Disulfiram
  • Short description
    Reversibly stimulates SERCA Ca2+-ATPase. V-ATPase inhibitor.
  • Biological description
    Reversibly stimulates SERCA Ca2+-ATPase. V-ATPase inhibitor (EC50 = 24.8 μM). Also inhibits aldehyde dehydrogenase and matrix metalloproteinases (MMP-2 and-9). Inhibits multidrug resistant P-glycoprotein and concanamycin A-sensitive ATP-hydrolysis. Displays antifungal, anticancer and anti-alcohol activity.
  • Biological action
    Inhibitor
  • Citations

Properties

  • Chemical name
    Bis(diethylthiocarbamyoyl)disulfide
  • Molecular Weight
    296.54
  • Chemical structure
    Disulfiram  [97-77-8]
  • Molecular Formula
    C10H20N2S4
  • CAS Number
    97-77-8
  • PubChem identifier
    3117
  • SMILES
    CCN(CC)C(=S)SSC(=S)N(CC)CC
  • InChi
    InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
  • InChiKey
    AUZONCFQVSMFAP-UHFFFAOYSA-N
  • MDL number
    MFCD00009048

Storing and Using Your Product

  • Storage instructions
    +4°C
  • Solubility overview
    Soluble in DMSO (20mM) and in ethanol (100mM)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Disulfiram

  • Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry.

    Johnson RM et al (2010) Anal Biochem 398(2) : 203-11.
    PubMedID: 20018164
  • Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression.

    Cho HJ et al (2007) J Biochem Mol Biol 40(6) : 1069-76.
    PubMedID: 18047805
  • Antifungal potential of disulfiram.

    Khan S et al (2007) Nihon Ishinkin Gakkai Zasshi 48(3) : 109-13.
    PubMedID: 17667894
  • The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo.

    Fisher SJ et al (2010) J Pharmacol Exp Ther 332(1) : 326-33.
    PubMedID: 19820208
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