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Product overview

  • Name
  • Short description
    Competitive EAAT blocker. Inhibits glutamate uptake.
  • Biological description
    Competitive, non-transportable EAAT blocker (IC50 values are 70, 6 and 6 µM for EAAT1, EAAT2 and EAAT3 respectively and Ki values are 4.4 and 3.2 µM for EAAT4 and EAAT5. Selective for EAA transporters over ionotropic and metabotropic glutamate receptors. Inhibits glutamate uptake.
  • Biological action
  • Purity
  • Citations


  • Chemical name
    DL-threo-β-Benzyloxyaspartic acid
  • Molecular Weight
  • Chemical structure
    DL-TBOA  [205309-81-5]
  • Molecular Formula
  • CAS Number
  • PubChem identifier
  • Source
  • InChi
  • InChiKey
  • Appearance
    Off-white solid

Storing and Using Your Product

  • Storage instructions
    -20°C (desiccate)
  • Solubility overview
    Soluble in DMSO (100mM, gentle warming) or water (5mM, gentle warming)
  • Important
    This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for DL-TBOA

  • Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers.

    Shimamoto K et al (2000) Bioorg Med Chem Lett 10(21) : 2407-10.
    PubMedID: 11078189
  • DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.

    Shimamoto K et al (1998) Mol Pharmacol 53(2) : 195-201.
    PubMedID: 9463476
  • Neurotoxic and neuroprotective effects of the glutamate transporter inhibitor DL-threo-beta-benzyloxyaspartate (DL-TBOA) during physiological and ischemia-like conditions.

    Bonde C et al (2003) Neurochem Int 43(4-5) : 371-80.
    PubMedID: 12742081
Our products in action
The following papers have cited the use of DL-TBOA (HB0258) from Hello Bio. If you have published a paper using this product, and it is not shown here, then please tell us! We will send you a free gift as a thank you!
  • The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.

    Sanderson et al (2018) Cell Rep. 25(13) : 3631-3646
    PubMedID: 30590038
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Reviews & Product Guides


  • Verified customer

    Reasonable price and it works as it should.