Product overview

  • Name
    DL-AP4
  • Short description
    Broad spectrum glutamate antagonist
  • Biological description
    Broad spectrum glutamate antagonist. Produces depolarizing responses in the cerebral cortex for a short time period after quisqualate application.
  • Alternative names
    2-amino-4-phosphonobutyrate; 2APB
  • Biological action
    Antagonist
  • Purity
    >98%
  • Our products in action

Properties

  • Chemical name
    DL-2-Amino-4-phosphonobutyric acid
  • Molecular Weight
    183.1
  • Chemical structure
    DL-AP4  [20263-07-4]
  • Molecular Formula
    C4H10NO5P
  • CAS Number
    20263-07-4
  • PubChem identifier
    2207
  • SMILES
    C(CP(=O)(O)O)C(C(=O)O)N
  • Source
    Synthetic
  • InChi
    InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
  • InChiKey
    DDOQBQRIEWHWBT-UHFFFAOYSA-N
  • MDL number
    MFCD00013999
  • Appearance
    White solid

Storing and Using Your Product

  • Storage instructions
    Room temperature
  • Solubility overview
    Soluble in water (33mM)

References for DL-AP4

  • Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog.

    Evans RH et al (1979) Br J Pharmacol 67(4) : 591-603.
    PubMedID: 316343
  • The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations.

    Evans RH et al (1982) Br J Pharmacol 75(1) : 65-75.
    PubMedID: 7042024
  • Anion transport blockers inhibit DL-2-amino-4-phosphonobutyrate responses induced by quisqualate in the rat cerebral cortex.

    Turner JP (1993) Br J Pharmacol 109(2) : 449-58.
    PubMedID: 7689393